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28 lis 2023 · The resulting M. musculus strain, named ‘Telomouse’, had shorter telomeres than those of wild-type M. musculus mice, reaching human length after 15 generations.
The common laboratory mouse Mus musculus has telomeres that are ~ five times longer than human telomeres, limiting its use for studying telomere biology. In a new study, researchers used a...
4 cze 2019 · Our findings demonstrate that AAV9-Tert treatment can ameliorate signs of neurodegeneration with aging in wild-type mice as well as in the context of the telomerase-deficient mouse model with the presence of short telomeres.
15 maj 2012 · Together, these results indicate that forced TERT expression in adult mice by using a gene therapy approach results in rescue of short telomeres in several tissues and prevention of telomere shortening in peripheral blood leukocytes from the same mice.
17 paź 2019 · Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal...
Length is not determined by whether a mouse is inbred or wild-derived, and it is not affected by how long an inbred strain has been domesticated. Indeed, various wild-derived mice have telomeres that are shorter or longer on average than those of C57BL/6J, one of the original inbred mouse strains.
1 wrz 2001 · Reconstitution of telomerase activity is proposed as a potential gene therapy to prevent, or rescue, age‐related diseases produced by critical telomere shortening. However, it is not known whether or not short telomeres are irreversibly damaged.
