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Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts [1, 2]. Bone exerts important functions in the body, such as locomotion, support and protection of soft tissues, calcium and phosphate storage, and harboring of bone marrow [3, 4].
4 mar 2024 · Bone cells are the cellular components of bone tissue. Bone cells play an important role in maintaining the bone tissue, which, in turn, supports the overall structure, movement, and mineral balance within the body.
1 maj 2023 · As a specialized connective tissue, bone is comprised of mainly type 1 collagen fibers and inorganic salts. Type 1 collagen is a non-calcified matrix designed to resist the tension experienced by the weight-bearing functions of bone. It forms from osteoblasts, the main cellular component of bone.
Bone is a mineralized connective tissue that exhibits four types of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts [1, 2]. Bone exerts important functions in the body, such as locomotion, support and protection of soft tissues, calcium and phosphate storage, and harboring of bone marrow [3, 4].
The bone matrix consists of tough protein fibers, mainly collagen, that become hard and rigid due to mineralization with calcium crystals. Bone matrix is crisscrossed by blood vessels and nerves and also contains specialized bone cells that are actively involved in metabolic processes.
The cell responsible for bone resorption, or breakdown, is the osteoclast. They are found on bone surfaces, are multinucleated, and originate from monocytes and macrophages, two types of white blood cells, not from osteogenic cells. Osteoclasts are continually breaking down old bone while osteoblasts are continually forming new bone.
The osteoblast is the bone cell responsible for forming new bone and is found in the growing portions of bone, including the periosteum and endosteum. Osteoblasts, which do not divide, synthesize and secrete the collagen matrix and calcium salts.
