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Rubella virus contains three major structural polypeptides: two membrane glycoproteins, E1 and E2 and a single nonglycosylated RNA-associated capsid protein, C, within the virion. One of the envelope proteins, E1, is responsible for viral hemagglutination and neutralization.
26 kwi 2021 · This review focuses on the life cycle of RUBV with emphasis on recent findings on the structures of the virus particle and its component proteins and on the mechanisms of virus entry, fusion, assembly, and budding.
Here we report a helical structure of rubella virions using cryo-electron tomography. Sub-tomogram averaging of the surface spikes established the relative positions of the viral glycoproteins, which differed from the earlier icosahedral models of the virus.
8 sie 2023 · Rubella virus encodes two non-structural proteins (p90 and p150) and three structural proteins; glycoprotein (E1 and E2) and the capsid protein (CP). The E1 protein is responsible for receptor-mediated endocytosis and induces the immune response through hemagglutination-neutralizing epitopes.
9 wrz 2010 · Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs.
Rubella virus contains three major structural polypeptides designated El, E2, and C with molecular weights of 62,000, 47,000-54,000 (a complex), and 38,000, respectively, as de-termined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reduced conditions. Limited-digest peptide maps confirm that each of these polypeptides is dis-
25 sty 2013 · Phylogenetic analysis confirmed genotype groupings originally based on structural protein coding region sequences, which provides support for the WHO nomenclature for genetic characterization of wild-type rubella viruses.
