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Structure. Rubella virus is a spherical, 40- to 80-nm, positive-sense, single-stranded RNA virus with spike-like, hemagglutinin-containing surface projections. An electron-dense 30 to 35 nm core is surrounded by a lipoprotein envelope. Classification and Antigenic Types.
26 kwi 2021 · This review focuses on the life cycle of RUBV with emphasis on recent findings on the structures of the virus particle and its component proteins and on the mechanisms of virus entry, fusion, assembly, and budding.
8 sie 2023 · Rubella, or German measles, is a mild viral infection that typically occurs in children and non-immune young adults. It typically begins with low-grade fever, malaise, and lymphadenopathy, followed by a brief generalized erythematous maculopapular rash.
Here we report a helical structure of rubella virions using cryo-electron tomography. Sub-tomogram averaging of the surface spikes established the relative positions of the viral glycoproteins, which differed from the earlier icosahedral models of the virus.
Rubella virus contains three major structural polypeptides designated El, E2, and C with molecular weights of 62,000, 47,000-54,000 (a complex), and 38,000, respectively, as de-termined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reduced conditions. Limited-digest peptide maps confirm that each of these polypeptides is dis-
Rubella virus has two envelope glycoproteins, E1 and E2 (481 and 282 amino acids long, respectively), which are anchored in the viral membrane by a carboxy-terminal transmembrane segment.
25 sty 2013 · Phylogenetic analysis confirmed genotype groupings originally based on structural protein coding region sequences, which provides support for the WHO nomenclature for genetic characterization of wild-type rubella viruses.
