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4 kwi 2018 · We establish a long evolutionary history for most groups of vertebrate RNA virus, and support this by evaluating evolutionary timescales using dated orthologous endogenous virus elements.
20 gru 2022 · RNA viruses are characterised by extremely high genetic variability due to fast replication, large population size, low fidelity, and (usually) a lack of proofreading mechanisms of RNA polymerases leading to high mutation rates.
6 dni temu · The study also uncovered some of the most complex RNA virus genomes ever identified, including one genome that was 47.3 kilobases long, among the longest RNA viruses discovered to date. Most RNA ...
11 paź 2024 · In 2022, Babaian and his colleagues searched 5.7 million genomic samples archived in publicly available databases and identified almost 132,000 new RNA viruses 2 . Other groups have led similar ...
25 lis 2021 · Coronaviruses are positive-strand RNA viruses with an unusually large genome of ~30 kb. They express an RNA-dependent RNA polymerase and a cohort of other replication enzymes and supporting...
6 paź 2021 · The replication in RNA viruses takes place by the generation of messenger RNA (mRNA) from their genome. The mRNA synthesizes numerous polyproteins that are cleaved into multiple proteins using either viral or cellular protease enzymes.
Using this approach, we identified 161,979 potential RNA virus species and 180 RNA virus supergroups, including many previously poorly studied groups, as well as RNA virus genomes of exceptional length (up to 47,250 nucleotides) and genomic complexity. A subset of these novel RNA viruses was confirmed by RT-PCR and RNA/DNA sequencing.
