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1 sty 2023 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.
- Rete Ridges
The findings reveal that this microstructure provides a stem...
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Skin is composed of two typical layers of dermis and...
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Staining of the epidermal cells of lesional skin from all...
- Rete Ridges
1 sty 2023 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.
Rete ridges surround the dermal papillae, which can be seen as small extensions protruding from the papillary dermis within the epidermis. These two structures are perfectly embedded; the alternation of a rete ridge with a dermal papilla creates a characteristic repetitive and wave-shaped pattern.
The epidermis consists of stratified squamous epithelium. That means it consists of layers of flattened cells. Skin, hair and nails are keratinised, meaning they have a dead and hardened impermeable surface made of a protein called keratin. Mucous membranes are non-keratinised and moist.
During human skin development, specific interactions between epidermal and dermal cell lineages give rise to fully functional skin that contains specialized appendages, including hair follicles, sweat glands, and rete ridges.
1 sty 2023 · The findings reveal that this microstructure provides a stem cell niche that regulates the pathways and promotes the expression of proteins related to epidermal stem cells. This work advances the functional properties of tissue engineered skin and holds promise for improving the therapeutic efficacy of artificial skin grafts for the skin wounds.
20 paź 2023 · Here, we report a micropatterning method to create human skin models replete with rete ridges between their epidermal and dermal layers. Using 3D printed stamps coupled with micromolding, we produced rete ridges composed of rounded features of controlled geometry and periodicity in the dermal layer.
