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1 sty 2023 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.
- Rete Ridges
The findings reveal that this microstructure provides a stem...
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Skin is composed of two typical layers of dermis and...
- An Insight Into Disease Severity
The epidermis in non-lesional skin sections of all the...
- Rete Ridges
Rete ridges surround the dermal papillae, which can be seen as small extensions protruding from the papillary dermis within the epidermis. These two structures are perfectly embedded; the alternation of a rete ridge with a dermal papilla creates a characteristic repetitive and wave-shaped pattern.
1 sty 2023 · Rete ridges (RRs) are distinct undulating microstructures at the junction of the dermis and epidermis in the skin of humans and certain animals. This structure is essential for enhancing the mechanical characteristics of skin and preserving homeostasis.
1 sty 2023 · The findings reveal that this microstructure provides a stem cell niche that regulates the pathways and promotes the expression of proteins related to epidermal stem cells. This work advances the functional properties of tissue engineered skin and holds promise for improving the therapeutic efficacy of artificial skin grafts for the skin wounds.
20 paź 2023 · Rete ridges consist of undulations between the epidermis and dermis that enhance the mechanical properties and biological function of human skin. However, most human skin models are fabricated with a flat interface between the epidermal and dermal layers.
We utilized a massively parallel, multi-species single-cell transcriptomics approach to identify the cellular signaling interactions that support rete ridge formation in humans and pigs but not mice. Validation of these mechanisms included in-vivo immunostaining, wound healing assays, and knockout pig models.
25 wrz 2013 · Key Points. Epidermal stem cells are essential for maintaining a constant supply of cells that ensure proper hair cycling and for the formation of the barrier provided by the skin. Epidermal...
