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Side effects. When higher doses are used, as in the treatment of toxoplasmosis, pyrimethamine can cause gastrointestinal symptoms such as nausea, vomiting, glossitis, anorexia, and diarrhea. [11][13] A rash, which can be indicative of a hypersensitivity reaction, is also seen, particularly in combination with sulfonamides. [11] .
Sensitivity reactions, occasionally severe (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, anaphylaxis) have been reported with pyrimethamine, especially when the drug was used with a sulfonamide.
T65.891A is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Short description: Toxic effect of substances, accidental (unintentional), init; The 2025 edition of ICD-10-CM T65.891A became effective on October 1, 2024.
T50.992A is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Short description: Poisoning by oth drug/meds/biol subst, self-harm, init; The 2025 edition of ICD-10-CM T50.992A became effective on October 1, 2024.
Toxicity. Pyrimethamine is very safe and well tolerated. Occasionally megaloblastic anaemia, neutropenia or thrombocytopenia may develop in patients with pre-existing folate deficiency.
The most notable toxicity of pyrimethamine is dose-related bone marrow suppression, resulting in thrombocytopenia, granulocytopenia, or megaloblastic anemia. 111–113 At doses of 75–100 mg/day, hematologic abnormalities should be anticipated but may be difficult to distinguish from those associated with HIV infection per se. Complete blood ...
16 lis 2012 · Pyrimethamine (Pyr) is a folate antagonist with a variety of indications. We report on the inadvertent poisoning of patients with Pyr who underwent bone marrow (BM) biopsy. There were 17 patients (median age 54); the most common presentation was gastrointestinal bleeding and pancytopenia.
