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Pyrimethamine is a folic acid antagonist that inhibits the dihydrofolate reductase of plasmodia and Toxoplasma gondii. It is used in combination with other drugs to treat malaria and toxoplasmosis.
Pyrimethamine is a folic acid antagonist that inhibits folic acid metabolism and DNA synthesis. It is used to treat toxoplasmosis, cystoisosporiasis, and Pneumocystis jiroveci pneumonia, among other conditions.
Pyrimethamine (Daraprim) is a diaminopyrimidine that acts as a folic acid antagonist. Its action on Toxoplasma is synergistic with sulfonamides. Pyrimethamine is readily absorbed from the gastrointestinal tract, is lipid-soluble, and is distributed throughout the cells of the body.
Pyrimethamine is an antimalarial and antiprotozoal drug that inhibits folic acid synthesis. It is used with sulfonamides or dapsone to treat malaria and toxoplasmosis. Learn about its mechanism of action, pharmacokinetics, toxicity, and resistance.
To dissect the mechanism of action of pyrimethamine as a STAT3 inhibitor, we first examined the effect of pyrimethamine on three major steps of the STAT3 signaling pathway, namely STAT3 tyrosine phosphorylation, STAT3 nuclear localization, and STAT3 DNA binding.
Pyrimethamine is an antimalarial drug that inhibits the enzyme dihydrofolate reductase (DHFR), which is essential for nucleic acid synthesis. Learn about its structure, synthesis, activity, and combination with sulfonamides from various chapters and articles on ScienceDirect Topics.
10 lut 2020 · Pyrimethamine is an antiparasitic drug that inhibits dihydrofolate reductase, a key enzyme in folate synthesis. It is used to treat and prevent toxoplasmosis, isosporiasis, and PCP in HIV-infected patients, and malaria in children.
