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19 cze 2001 · Heparin was administered as an initial 5000-U IV bolus, followed by IV infusion of 1000 U/h, adjusted to maintain the aPTT at 1.5 to 2.0 times the control value. Treatment was initiated within 24 hours after the onset of chest pain and continued for ≈6 days.
8 cze 2024 · Normal PTT values range from 25 to 35 seconds. Prolonged PTT may signify deficiencies in these clotting factors, hemophilia, or the presence of inhibitors. Shortened PTT, on the other hand, may indicate an increased risk of thrombosis and could be associated with elevated factor VIII levels.
14 sie 2023 · While protocols vary from institution to institution, the therapeutic PTT range for heparin is 60 to 100 seconds, with lower-intensity dosing in the range of 60 to 80 seconds. Screening for Bleeding Disorders
We review the essential factors affecting test results; provide a practical approach to the evaluation of a prolonged PT, APTT, and BT; and offer suggestions on which reflexive tests are appropriate and when to consider a subspecialty consultation.
Titration is based on the PTT value, with a goal PTT of ~1.5-2.5 times normal (table below). Make sure to obtain a baseline PTT before starting the argatroban infusion (and possibly a thrombin time as well).
1. STOP HEPARIN INFUSION. 2. Order repeat STAT PTT hourly until PTT <100. 3. Then, resume infusion at DECREASED dose that is 4 units/kg/hr lower than previous dose and repeat PTTin 6 hours.
Dosing information: 60 units/kg bolus (maximum 4000 units) followed by an intravenous infusion of 12 units/kg per hour (maximum 1000 units per hour), adjusted to target APTT. On initiation of infusion, check the APTT RATIO after 4 to 6 hours.
