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How to convert human dose to animal dose? The common perception of scaling of dose based on the body weight (mg/kg) alone is not the right approach. This is primarily because the biochemical, functional systems in species vary which in turn alter pharmacokinetics.
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Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one ...
30 cze 2022 · The authors describe four approaches to selecting a safe starting dose for humans in clinical drug trials based on interspecies scaling of clearance.
The dose by factor method applies an exponent for body surface area (0.67), which account for difference in metabolic rate, to convert doses between animals and humans.
1 mar 2016 · The standard conversion factors are included to allow dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m2.
dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m 2. The estimation of a safe starting dose is important to ensure the safety and tolerability of humans during phase-I clinical trials. Keywords: Starting dose, Body surface area, Dose translation, Human equivalent dose,
The effective dose which was achieved in the current study is rather high, 700 mg/kg, which will be translated to the human dose of 113.5 mg/kg (Nair and Jacob 2016). However, considering the...
