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10 sie 2021 · These advanced in vitro models will facilitate investigations into previously inaccessible developmental processes and disease aetiologies, and, in turn, mediate the discovery and preclinical...
Here, we describe an efficient in vitro system to propagate a large number of highly purified murine memory monocytes through sustaining bone marrow–derived monocytes with macrophage colony-stimulating factor (M-CSF, 10 ng/mL)-containing medium, together with other polarization agents such as lipopolysaccharide (LPS) for a 5-day period.
16 kwi 2024 · Despite their emerging relevance, robust in vitro systems in clearly capturing monocyte memory generation and underlying mechanisms are limited. Here, we describe a robust and efficient in vitro culture system for sustaining the generation of murine memory monocytes .
1 lip 2023 · Here we highlight the utility of mathematical inference to derive quantitatively testable models of mammalian CD8 + T cell memory development from complex experimental data. Previous inference studies suggested that precursors of memory T cells arise early during the immune response.
8 lis 2021 · Multicellular in vitro models are beginning to replicate key aspects of human brain tissue and are increasingly complementing existing approaches to provide new molecular and cellular...
30 lip 2021 · Abstract. The complexity of the human brain creates significant, almost insurmountable challenges for neurological drug development. Advanced in vitro platforms are increasingly enabling researchers to overcome these challenges, by mimicking key features of the brain's composition and functionality.
28 cze 2023 · Three-dimensional (3D) in vitro models of the human brain, such as organoids, cerebral organoids, three-dimensional bioprinted brain models, and functionalized brain organoids, have the potential to provide a platform for the study of human brain development, physiology, and disease.
