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I really thought that because of all of the well-documented adverse effects of progestins — from pyometra to diabetes mellitus to mammary cancer — these medications had been withdrawn from our armamentarium.
Reported side effects of prolonged megestrol acetate treatment in cats included: increased appetite leading to weight gain; lethargy or restlessness (Burke, 1982); marked mammary stimulation...
Use of progesterone-based medications in cats--neutered or otherwise. J Feline Med Surg. 2011 Jul;13 (7):536. doi: 10.1016/j.jfms.2011.05.005.
The major limitations of progestins are the intensity and severity of side effects that vary in relation to the drug, dose, frequency and phase of the estrous cycle in which given and pre-existing medical conditions.
While progesterone can be beneficial for cats when used appropriately, there are also potential risks to take into consideration. Overdosing on progesterone can lead to side effects such as lethargy, vomiting, and loss of appetite. In female cats, prolonged use of progesterone may increase the risk of mammary tumors.
4 cze 2009 · Side effects have included premature luteal failure, shortened diestrus, and pregnancy loss.38, 39 Long-term use is also associated with pituitary overstimulation, downregulation of GnRH receptors, suppression of LH, decreased progesterone secretion, and decreased luteal responsiveness to LH. 1
20 kwi 2018 · This review summarizes the methods currently available for use as reversible contraception in dogs and cats, along with cautions about reported side effects. The products covered include synthetic steroid hormones, peptide hormone agonists, vaccines, and a barrier method.
