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1 cze 2019 · This is the first report showing CA8-204C codes for a functional peptide sufficient to regulate calcium signaling and produce profound analgesia, and surprisingly, this peptide inhibited ITPR1 (pITPR1) activation, IT PR1-mediated calcium release in vitro; and produced profound analgesIA in vivo.
14 cze 2019 · We showed previously that murine nociception and analgesic responses are regulated by the expression of this gene in dorsal root ganglion (DRG) associated with a cis-eQTL. In this report, we...
14 cze 2019 · In this report, we identify an exon-level cis -eQTL (rs6471859) that regulates human DRG CA8 alternative splicing, producing a truncated 1,697bp transcript (e.g., CA8-204). Our functional genomic studies show the “G” allele at rs6471859 produces a cryptic 3’UTR splice site regulating expression of CA8-204.
Minimal cardiorespiratory depression and a profound analgesic effect make ketamine a candidate for procedural sedation; however, unpleasant psychiatric adverse effects prevent its use as monotherapy. Propofol–ketamine combinations have been explored and appear to have fewer adverse respiratory events when compared with propofol. 21
Sedation allows the depression of patients’ awareness of the environment and reduction of their response to external stimulation. It plays a pivotal role in the care of the critically ill patient, and encompasses a wide spectrum of symptom control that will vary between patients, and among individuals throughout the course of their illnesses.
4 kwi 2022 · Multimodal analgesia involves the administration of multiple medications each with a unique mechanism of action which when administered concomitantly may provide profound analgesia.
25 paź 2020 · When performed in concert, analgesia and conscious sedation allow the performance of procedures that may be otherwise poorly tolerated by patients of all ages. Herein is provided a brief summary of the medications and techniques required to perform sedation and analgesia in a safe and effective manner.
