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  1. Approximate pKa chart of the functional groups: values to know. Protonated carbonyl pKa = ‐7. Other important pKa’s. 2. Protonated alcohol or ether pKa = ‐2 to ‐3. H2 = 35. 3. Carboxylic acid pKa = 4‐5.

  2. pKa Data Compiled by R. Williams pKa Values INDEX Inorganic 2 Phenazine 24 Phosphates 3 Pyridine 25 Carboxylic acids 4, 8 Pyrazine 26 Aliphatic 4, 8 Aromatic 7, 8 Quinoline 27 Phenols 9 Quinazoline 27 Alcohols and oxygen acids 10, 11 Quinoxaline 27 Amino Acids 12 Special Nitrogen Compounds 28 Peptides 13 Hydroxylamines 28 Nitrogen Compounds 14 ...

  3. Alcohols and phenols, like water, can form hydrogen bonds: non covalent interaction between a hydrogen atom (δ+) involved in a polar covalent bond, with the lone pair of a heteroatom (usually O or N), which is also involved in a polar covalent bond (δ-) O H. N H.

  4. Acidity of alcohols. As the pKa values above show, phenol is 108 more acidic than cyclohexanol. Phenol has a pKa value of 10 (given this information, you should immediately recognize that it is more much acidic (about 6 orders of magnitude) than water (pKa 15.7) and methanol (pKa 16) since it has lower pKa value).

  5. 27 paź 2017 · Below are tables that include determined pKa values for various acids as determined in water, DMSO and in the gas Phase. These tables are compiled in PDF files below. For a more comprehensive discussion on this topic, please see Acidity and Basicity by professor William Reusch, Michigan State University.

  6. Alcohol Group: For a molecule with an oxygen atom in an sp3 hybridized state connected to another sp3 hybridized carbon, you’re dealing with an alcohol. Estimate its pKa to be around 16, given that primary alcohols typically have pKa values near 16. Carboxylic Acid: Recognize a carboxylic acid by the presence of the carboxyl functional group ...

  7. Learn the values in an “open-book” manner. Have a pK a values reference chart by your side as you work on drill problems similar to what is shown below and refer to the chart when necessary. You will probably be surprised by how quickly you memorize the essential pK a values when you do it this way because you will see