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View full text | Download PDF. ABSTRACTAs a major etiological agent of human dental caries, Streptococcus mutans resides primarily in biofilms that form on the tooth surfaces, also known as dental plaque. In addition to caries, ...
1 gru 2003 · Describes the use of genetic manipulation in combination with an animal model to show the importance of the cell-surface anchoring of proteins in the ability of S. mutans to cause caries.
5 sie 2009 · Streptococcus mutans is the major pathogen of dental caries, and it occasionally causes infective endocarditis. While the pathogenicity of this species is distinct from other human pathogenic streptococci, the species-specific evolution of the genus Streptococcus and its genomic diversity are poorly understood.
18 sty 2019 · In these areas of research, S. mutans has served as a model organism for ground-breaking new discoveries that have, at times, challenged long-standing dogmas based on bacterial paradigms such as Escherichia coli and Bacillus subtilis.
S. mutans and S. sobrinus are the predominant pathogenic species in humans, with S. mutans serotype c being the most common isolate (70–80%) from carious lesions. Serotype is based on the chemical compositions of surface polysaccharides, which are composed of a rhamnose backbone and glucose side chains.
As a human pathogen, S. mutans is also implicated in subacute bacterial endocarditis, a life-threatening inflammation of heart valves, while a subset of strains has been linked to other extraoral pathologies such as cerebral microbleeds, IgA nephropathy, and atherosclerosis.
1 sie 2014 · The obtained results allow for better differentiation of S. mutans species and thus may contribute to recognition of pathogenic bacteria transmission mechanisms and facilitate treatment.
