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CLASSIFICATION. USE. DOSE (for cats and dogs unless otherwise noted) Chlorpromazine. Alpha-2 adrenergic antagonist D2 dopaminergic antagonist H1 histaminergic antagonist M1 muscarinic cholinergic antagonist. Antiemetic. 0.2–0.4 mg/kg SC or IM Q 8 H. Cisapride. 5-HT4 serotonergic agonist.
Description: Antiemetic. Other Names for this Medication: Zofran®. Common Dosage Forms: Veterinary: None. Human: Tablets: 4 mg, 8 mg, 16 mg, & 24 mg; Orally disintegrating tablets: 4 mg & 8 mg; Oral Liquid: 4 mg/5 mL (0.8 mg/mL). A compounded topical gel may be available.
Ondansetron (brand names Zofran®, Zuplenz®) is an antiemetic used off label (extra label) to treat severe nausea and vomiting in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine.
There have been no placebo-controlled clinical trials of ondansetron dosing for cats. The famous 2014 Quimby, et al, study on ondansetron pharmacokinetics for oral, subcutaneous, and IM administration(31) found that a previously published recommended oral dosage of 0.5 mg/kg twice a
For acute vomiting: 2 mg/kg, PO, or 1 mg/kg, SC, q 24 h (acute vomiting); 8 mg/kg/day, PO, for up to 2 days (motion sickness) For motion sickness: 8 mg/kg, PO, q 24 h for up to 2 d. *Dogs with ABCB1 polymorphism may be predisposed to adverse events. In these topics.
The dosage should be carefully observed, especially in cats and small breed dogs. Following prolonged vomiting, consideration should be given to fluid and electrolyte replacement therapy. In case of vomiting after intake of the oral solution, maintain the usual interval between two administrations before administering the product again.
1 mar 2010 · Ondansetron is available as a 2 mg/ml injectable, 4 mg tablets and an oral solution (4 mg per 5 ml). The empirical dosage in cats is 0.5 mg/kg bid. Dolasetron is supplied as an injectable and as 50 mg tablets, which must be reformulated for use in cats. The empirical dosage is 0.6–1.0 mg/kg IV or PO sid.
