Search results
12 lis 2019 · A2B5 recognises progenitor cells, NPC and oligodendrocyte progenitor cells (OPC), while oligodendroglial cell lineage markers Olig1 and 2 as well as Sox10 and Nkx2.2 are expressed in all cells of the lineage, OPC and pre-oligodendrocytes (pre-OL) are characterised by PDGFR-α and NG2 expression.
6 lis 2014 · Highlights. •. White matter oligodendrocytes show very limited turnover. •. Nuclear bomb test-derived 14 C reveals a high exchange rate of myelin. •. Oligodendrocyte turnover has little influence on myelination in humans. •. Myelin modulation may be carried out by mature oligodendrocytes in humans. Summary.
The sheer numbers of oligodendrocytes in humans are dramatically increased (although the density of oligodendrocytes per mm 3 is remarkably similar between rodents and humans) [140, 176]. Human and rodent OPCs might respond differently to certain factors [6, 168, 205, 213]. This can be shown best in the case of CXCL1.
7 cze 2024 · These ectopic oligodendrocytes (eOLs) have a distinctive gene expression profile as well as subtle myelination abnormalities.
10 kwi 2022 · Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) and myelinate the axons facilitating and boosting the propagation and speed of nerve conduction. In addition, the OLs also provide metabolic support to neurons and enhance their...
27 kwi 2022 · Oligodendrocytes (OLs) are metabolically active cells that both myelinate and provide trophic support to neurons, as well as supply metabolites to neurons and other cells of the CNS. Many metabolic factors can alter OL function including (but not limited to): glucose and lipid metabolism, reactive oxygen species (ROS) that can generate pro- or ...
12 lis 2019 · Here, we review the journey of oligodendrocytes from the embryonic stage to their role in homeostasis and their fate in disease. We will also discuss the most common models used to study oligodendrocytes and describe newly discovered functions of oligodendrocytes.
