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Vocabulary Term Definition Mutation Point Mutation Frameshift Mutation Missense Mutation Silent Mutation Nonsense Mutation Part 2. Practice Directions: Complete the boxes below by finding the mRNA and amino acid sequence. Compare the mutant DNA strands to the original strand. Circle the mutation in the mutant DNA strands.
o If a substitution does not change the amino acid, it’s called a SILENT mutation. o If a substitution changes the amino acid to a “stop,” it’s called a NONSENSE mutation.
There are three main types of mutations: point missense mutations, point nonsense mutations, and frameshift mutations. In each of the following DNA sequences, you will use the mRNA and amino acid
If a mutation changes the amino acid, it’s called a MISSENSE mutation. If a mutation does not change the amino acid, it’s called a SILENT mutation. If a mutation changes the amino acid to a “STOP,” it’s called a NONSENSE mutation.
If a substitution changes the amino acid, it’s called a MISSENSE mutation. If a substitution does not change the amino acid, it’s called a SILENT mutation. If a substitution changes the amino acid to a “stop,” it’s called a NONSENSE mutation.
Nonsense mutation: A nonsense mutation is also a change in one DNA base pair. Instead of substituting one amino acid for another, however, the altered DNA sequence prematurely signals the cell to stop building a protein (Figure \(\PageIndex{1}\)).
(a) A SUBSTITUTION mutation, occurs where one nucleotide base is replaced by another. These are often called “point mutations”, because a single base is changed, at one point in the gene. SOMETIMES, these base (A,T,C,G) substitutions lead to “Missense” or “Nonsense” mutations:
