Search results
The mTOR signaling pathway is an intricate signaling network activated by insulin, growth factors, and other cues that plays a central role in various biological processes. It controls cell growth, proliferation, survival, and cytoskeletal organization in response to environmental cues.
11 cze 2024 · Additionally, we highlight findings on the mechanisms by which mTOR is involved in protein synthesis and delve into mTOR-mediated processes occurring in MM. Finally, we summarize the progress and current challenges of drugs targeting mTOR complexes in MM.
10 mar 2020 · Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin resistance, osteoporosis, and other diseases.
15 lip 2023 · Here, we present the current available data regarding the mTOR expression regulation at the level of transcription, translation and mRNA stability and systematize the current knowledge about the fluctuations of mTOR expression observed in several diseases, both cancerous and non-cancerous.
11 maj 2023 · The most widely used anti-angiogenic agents include monoclonal antibodies and tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF) pathway.
14 lip 2023 · In recent years, several mTOR inhibitors have been developed with the aim of treating different cancers. In this review, we will explore the current developments in the mTOR signalling pathway and its importance for being targeted by various inhibitors in anti-cancer therapeutics.
1 sty 2010 · The cellular proliferation, survival, and migration required for vascular sprouting and endothelial cell differentiation leading to tube formation are primarily driven by VEGF/VEGF receptor (VEGF-R) activation that in turn activates the PI3K/Akt/mTOR pathway.
