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23 sty 2023 · Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of DRGs are ...
23 lut 2024 · The histopathological examination of tissue is the cornerstone of cancer diagnosis globally. It is based on the staining of tissue samples with histochemical dyes, such as haematoxylin and eosin (H&E), to highlight cellular components for visual interpretation by pathologists.
21 cze 2024 · Additionally, we opted to use mouse DRG marker genes for the cell-type nomenclature because mouse is the most commonly used mammalian model system, a majority of the current atlas is composed of cells/nuclei from mice, and Cre lines driven by these marker genes are available for most subtypes to help characterize their function in a range of ...
The dorsal root ganglion (DRG) houses the cell bodies of primary sensory neurons and projects axons to both the peripheral site of injury and the dorsal horn of the spinal cord. Hence, it is conceivable that the DRG is a major site of nociceptive processing in both adaptive and maladaptive pain states.
14 sty 2020 · Abstract. Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured sensory neurons in dorsal root...
11 lut 2016 · Here, we describe a simple, step-by-step protocol for the swift isolation of mouse DRG, which can be enzymatically dissociated to produce fully differentiated primary neuronal cultures, or processed for downstream analyses, such as immunohistochemistry or RNA profiling.
The expression of the Na V 1.8 channel subtype gene SCN10A, was much lower in human DRG, when compared to gene expression levels reported in mouse studies. In contrast, the expression of the Na V 1.7 channel subtype gene SCN9A, was much higher in human than mouse samples ( Chang et al., 2018 ).
