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11 lut 2016 · Here, we describe a simple, step-by-step protocol for the swift isolation of mouse DRG, which can be enzymatically dissociated to produce fully differentiated primary neuronal cultures, or processed for downstream analyses, such as immunohistochemistry or RNA profiling.
4 mar 2024 · We used this resource to reveal a remarkable degree of morphological and physiological diversity across the transcriptionally distinct DRG neuron subtypes. This mouse DRG neuron toolkit should enable analyses of the neuronal building blocks of somatosensation.
23 sty 2023 · We generated a transcriptome atlas of mouse, guinea pig, cynomolgus monkey, and human DRGs by implementing a common laboratory workflow and multiple data-integration approaches to generate...
21 cze 2024 · As implicated by the overlap in enriched cell-type–specific gene ontology terms between species (fig. S8E), the evolutionarily conserved expression patterns of these genes suggest that functional studies of these genes in mice DRG/TG could be predictive in many cases to their function in humans.
In the present study, we performed anatomical analyses of two types of sensory ganglia, the dorsal root ganglia and the trigeminal ganglia. Hematoxylin and eosin (H&E) staining revealed structural differences between ganglia and nerve fibers.
1 lis 2024 · Here we provide information to choose an appropriate AAV and detail an approach to inject AAVs into the L3 and L4 DRGs of C57Bl/6 J mice for the transduction of DRG cell bodies, the main source of somatosensory neurons in the murine sciatic nerve.
27 gru 2013 · A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year.
