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Serious adverse reactions and complications from smallpox vaccine can result in death in rare cases . Based on historical data, the death rate following smallpox vaccination is approximately one death per million persons receiving an initial dose and one death per four million among persons receiving another dose after the first dose .
30 mar 2023 · The studies suggested that smallpox is 80.7% efficacious to prevent human monkeypox and the immunity provided by prior smallpox vaccination is long-lasting. Moreover, the smallpox vaccination decreases the risk of human monkeypox by 5.2-folds.
11 sie 2003 · The Neff study reported 3 accidental infections from 517 vaccinations in the age group 1 to 4 years (CR, 5803 cases per million; 95% CI, 1198–16,863). For all age groups combined, there were no deaths among 857 cases of accidental infection (CFR, 0 deaths per 100 cases; 95% CI, 0.0–0.4).
It is hard to prove such claims because of the limited amount of high-quality data on both life expectancy and smallpox cases or deaths before the smallpox vaccine was developed in 1796 and adopted across countries. The high case fatality rate of approximately 30% (of the variola major virus) meant that smallpox shortened the lives of many.
Deaths from smallpox are generally due to secondary infection of lesions, pneumonia, toxemia, and hypotension. Death rates in unvaccinated patients, particularly those with the more severe form of the disease, can be as high as 50 percent.
28 lis 2022 · The strength and longevity of smallpox vaccination campaigns globally, combined with current demographic heterogeneity, have shaped the epidemiological landscape today, revealing substantial geographical variation in orthopoxvirus susceptibility.
17 sie 2023 · Summary. What is already known about this topic? Childhood smallpox vaccination confers some cross-protection against mpox. Although persons aged >50 years likely received childhood smallpox vaccination, they might have more comorbidities and a higher risk for severe mpox compared with those aged ≤50 years.
