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11 lis 2021 · The formation of the human brain—from a microscopic tube of neuroepithelial cells to a complex structure of ∼170 billion cells of diverse types and numerous synaptic connections—is a feat of coordinated cellular and molecular development.
The morphological and physiological characteristics of the mitospores of M. sextelata were similar to those of the microconidia of most ascomycete fungi: small cell structures, thin homogeneous cell wall structure, no pigments in the outer layer of the cell wall and mononuclear nature [2,33,58,59,60,61,62].
5 paź 2023 · Lancaster and colleagues investigated this form-fate relationship in brain organoids, revealing that tissue morphology and cell positioning in space influence the progression of cell identity in time.
17 paź 2022 · Organoids are 3D human cell culture models that originate from pluripotent stem cells and recapitulate the hallmarks of human neurodevelopment, enabling studies of human brain development in...
24 mar 2021 · We show that ZEB2 promotes neuroepithelial transition, and its manipulation and downstream signaling leads to acquisition of nonhuman ape architecture in the human context and vice versa, establishing an important role for neuroepithelial cell shape in human brain expansion.
6 paź 2021 · Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both...
Taken together, human retinal organoids strongly emulate the developmental timing, cell type composition, morphology, and electrophysiology of their in vivo counterparts. Human retinal organoids have been used to shed light on human retinal tissue development and cell type fate specification.
