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22 mar 2023 · Although most international asthma guidelines advise that children ≤5 years with asthma be treated with daily low- moderate dose inhaled corticosteroids (ICS) as the preferred controller and montelukast as an alternative therapy.
We consider as inclusion criteria: studies including children and adolescents (aged <18 years) with a diagnosis of asthma or allergic rhinitis, comparing montelukast with other treatments or placebo, with or without randomisation, and with at least one end-point measured with a validated PROM.
We found five systematic reviews evaluating the efficacy of montelukast or LTRA specifically on paediatric asthma patients [13, 2023], confirming the superiority of ICS in symptom control [20, 21, 24], – symptom scores [13], symptom-free days [24], night-time awakening [24] and HRQoL [24].
11 sty 2024 · A triad of wheezing, shortness of breath, and cough indicates pediatric asthma. [2] . In adults, the diagnosis of asthma can be confirmed by spirometric evaluation, but managing asthma is challenging in pediatric patients.
20 wrz 2017 · Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis.
6 gru 2021 · The use of theophylline to treat chronic childhood asthma is problematic due to potentially serious short-term side effects (eg, cardiac arrhythmias, seizures, death) and long-term adverse effects (learning and behavior disorders). A further encumbrance of theophylline is the need for frequent serum monitoring to maintain a serum concentration ...
23 paź 2023 · The initial evaluation and diagnosis of asthma, use of quick-relief medications, and management of acute exacerbations in children are all discussed separately. A general overview of asthma management and control of triggers are also presented separately, as is the management of asthma in adolescents and adults.
