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19 sie 2020 · Here, we review the virology of mumps, licensed mumps vaccines, and the typical immune responses elicited following mumps vaccination. Furthermore, we discuss the limitations and challenges of the currently licensed mumps vaccines and provide strategies for the development of an improved mumps vaccine.
Mumps is caused by the mumps virus (MuV), a member of the Paramyxoviridae family of enveloped, non-segmented, negative-sense RNA viruses. Mumps is characterized by painful inflammatory symptoms, such as parotitis and orchitis.
31 sty 2005 · These vaccines are produced by growing the virus in cell cultures or in embryonated chicken eggs. The virus is then purified, formulated with a stabilizer such as gelatine or sorbitol and lyophilized. Mumps vaccines are available as a monovalent vaccine, a bivalent measles-mumps vaccine, or as a trivalent measles-mumps-rubella vaccine (MMR).
26 lut 2020 · Mumps is an acute viral infection characterized by inflammation of the parotid and other salivary glands. Persons with mumps are infectious from 2 days before through 5 days after parotitis onset, and transmission is through respiratory droplets.
10 mar 2014 · To understand the biological characterization of the isolated SP-A virus exhibited by immunization with the new mumps vaccine, we performed viral nucleic acid detection in throat swabs collected at days 0, 4, 7, 10, 14, and 28 post-vaccination from all of the vaccine-immunized individuals.
This review considers the disease burden due to mumps; summarizes studies on the immunogenicity, efficacy, and safety of different strains of mumps vaccine; and highlights lessons learned about implementing mumps immunization in different countries.
Mumps vaccine is given in combination products with measles and rubella immunization (i.e., MMR vaccine) or with measles, rubella, and varicella immunization (i.e., MMRV vaccine). Complete mumps immunization is particularly important for children approaching puberty.
