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23 lip 2015 · MBL can be categorized as either low count or high count based on whether the B-cell count is above or below 0.5 × 10 9 /L. Low-count MBL can be detected in ∼5% of adults over the age of 40 years when assessed using standard-sensitivity flow cytometry assays.
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- Introduction to a Series of Reviews on Chronic Lymphocytic Leukemia
In recognition of the rapid changes that have occurred in...
- Targeted Therapies in CLL
In diffuse large B-cell lymphoma cell lines with either BTK...
- Initial Treatment of CLL
Development of lymphocytosis does not appear to be...
- Volume 126, Issue 4
View Article titled, Monoclonal B-cell lymphocytosis and...
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MBL is rare in people under 40 years of age (2- 3 per 1000 people) but becomes more common afecting 5-9% of people over the age of 60 years. Other risk factors for MBL are a family history of CLL, and infections particularly hepatitis C.
11 lis 2021 · The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 109/L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL.
13 paź 2022 · Key Points. After a median of 10.0 years of follow-up, low-count MBL had a significant 4.3-fold increased risk of lymphoid malignancies. After a median of 34.4 months of follow-up, there was no evidence of an association of low-count MBL with overall survival.
5 lip 2019 · Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature CD5 + CD23 + B...
12 lut 2014 · After a median follow-up of 4 years for patients with MBL and CLL and 3 years for controls, hospitalization owing to serious infections was noted to occur more among patients with MBL (16%) and CLL (18%) than among controls (2.6%).
6 lip 2023 · Monoclonal B cell lymphocytosis (MBL) refers to a monoclonal population of B lymphocytes <5000 cells/microL (<5 x 10 9 /L) in peripheral blood for ≥3 months, without other features of a B cell lymphoproliferative disorder (eg, lymphadenopathy, organomegaly, cytopenias, or extramedullary involvement) [1,2].
