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Patients with a history of immunosuppression should be tested for progressive multifocal leukoencephalopathy by cerebrospinal fluid (CSF) examination for the presence of JC virus. A high index of suspicion should remain for neoplasia, including primary central nervous system (CNS) lymphoma and gliomatosis cerebri.
13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
19 lip 2021 · Although no improvement in functional outcomes was shown, the trial elucidated that benefits of intervention depend on surgical performance: a greater ICH reduction, defined as ≤ 15 mL end of treatment ICH volume or ≥70% volume reduction, correlated with significant functional improvement.
23 gru 2021 · Demographics, neurological symptoms on admission and at time of discharge, along with imaging findings, time to onset, type of endovascular treatment and applied materials, and possible detection of a foreign body or allergic reaction were extracted from the corresponding studies when available.
27 gru 2022 · A pooled analysis of 38 studies comprising 20,322 patients prescribed antithrombotics after ischemic stroke or transient ischemic attack (TIA) found rapidly increasing ICH risk with CMB burden, 75 and showed that a CMB-based model (MICON-ICH) outperformed existing bleeding risk models in ICH prediction. 76 However, CMBs were also associated ...
1 paź 2020 · A combined measure of microvascular brain disease was defined at each visit and categorized by progression from first to second brain MRI as no progression; mild progression (increase of ≥1 unit in WMH grade or new lacune), and moderate progression (increase of ≥1 unit in WMH grade and new lacune).
