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Patients with a history of immunosuppression should be tested for progressive multifocal leukoencephalopathy by cerebrospinal fluid (CSF) examination for the presence of JC virus. A high index of suspicion should remain for neoplasia, including primary central nervous system (CNS) lymphoma and gliomatosis cerebri.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
21 lut 2024 · A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes.
More than 100 heritable disorders can present with abnormal white matter on neuroimaging. While acquired disorders remain a more common cause of leukoencephalopathy in the adult than genetic causes, the clinician must remain aware of features that suggest a possible genetic etiology.
Revascularisation was achieved using a single pass in 44%. When compared with the anterior circulation, posterior thrombectomy procedures were associated with a significant higher rate of extravasation (9% vs 4%, p<0.01) and post-procedural symptomatic Intracerebral Hemorrhage (ICH) (13% vs 4 %, p<0.01).
1 paź 2024 · Our study revealed a rescue EVT rate of only 6.9%, which is less than the previously reported rate of 10–20% for END [13,43]. This difference could have arisen from the nature of non-randomized controlled trials (RCTs) and the lack of standardized intervention methods in the referenced studies.
