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13 maj 2019 · Longitudinal studies with detailed risk factor assessment and lesion monitoring are needed to determine reasons for the wide variation in rates of progression of small vessel disease lesions, why some lesions regress, and why some lesions lead to secondary damage in remote brain regions.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
28 sie 2020 · Leukoaraiosis (LA) severity is associated with poor outcome after mechanical thrombectomy (MT) for acute ischemic stroke (AIS) caused by large vessel occlusion. This meta-analysis aimed to assess the association of LA severity with AIS-related risk factors and outcomes of MT. Methods.
19 lip 2021 · Although no improvement in functional outcomes was shown, the trial elucidated that benefits of intervention depend on surgical performance: a greater ICH reduction, defined as ≤ 15 mL end of treatment ICH volume or ≥70% volume reduction, correlated with significant functional improvement.
Contrary to our findings, a prior meta-analysis by Xiong et al 26 showed that patients with ELVO with minor or mild symptoms (NIHSS ≤8) who underwent MT had a significantly better 90-day mRS score at the cost of higher rate of sICH compared with those who received bMM.
Juvenile and adult (late) forms of the disease have a milder, more varied phenotype, a slower rate of progression and a significantly longer lifespan (although we have observed a rapid deterioration over a year in one case). Typical features include spasticity, dementia, ataxia, peripheral neuropathy and visual loss.
17 sie 2021 · Since the characterization in the late 1990s of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, several other monogenic conditions leading to adult-onset ischemic or hemorrhagic stroke have been described.
