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Patients with a history of immunosuppression should be tested for progressive multifocal leukoencephalopathy by cerebrospinal fluid (CSF) examination for the presence of JC virus. A high index of suspicion should remain for neoplasia, including primary central nervous system (CNS) lymphoma and gliomatosis cerebri.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
7 paź 2021 · The severity of PVS is typically assessed on axial T2-weighted images using a validated 4-point visual rating scale based on the total number of PVS (0 indicating no PVS; 1 [mild], ≤10 PVS; 2 [moderate], 11–20 PVS; 3 [moderate to severe], 21–40 PVS; and 4 [severe], >40 PVS) in the basal ganglia and centrum semiovale . 33 The topography of ...
Post-ischemic Leukoencephalopathy after Endovascular Treatment for Acute Ischemic Stroke. Can J Neurol Sci. 2019 May;46 (3):363-365. doi: 10.1017/cjn.2019.30.
More than 100 heritable disorders can present with abnormal white matter on neuroimaging. While acquired disorders remain a more common cause of leukoencephalopathy in the adult than genetic causes, the clinician must remain aware of features that suggest a possible genetic etiology.
27 gru 2022 · A pooled analysis of 38 studies comprising 20,322 patients prescribed antithrombotics after ischemic stroke or transient ischemic attack (TIA) found rapidly increasing ICH risk with CMB burden, 75 and showed that a CMB-based model (MICON-ICH) outperformed existing bleeding risk models in ICH prediction. 76 However, CMBs were also associated ...
