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16 sie 2023 · In neuropathic pain, microglial cells have an important role in initiating and maintenance of pain and inflammation. The interaction between neural and microglial cells has been proven extremely crucial for chronic pain.
- Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes ...
Cumulative studies from our laboratory illustrated that...
- Microglia in Pain: Detrimental and protective roles in pathogenesis and ...
Another striking difference between pain and other...
- Role of microglia in diabetic neuropathic pain - PMC
In addition, cilnidipine inhibited endogenous P2X7R...
- Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes ...
8 lut 2018 · Collectively, these findings suggest that targeting spinal microglia selectively prevents the undesirable side effects of chronic opioid use without reducing their pain-relieving effect.
31 sie 2021 · Cumulative studies from our laboratory illustrated that GLP-1R agonism could effectively relieve pain hypersensitivity through increasing the biomarkers of M2 in microglia associated with expression of IL-10, CD206, IL-4, and Arg1 [10–13].
12 gru 2018 · Another striking difference between pain and other neurological diseases is the rapid onset of pain: microglia regulate neuronal and synaptic activities to change pain behavior within minutes to tens of minutes following treatment with microglial activators and inhibitors (Berta et al., 2014; Tsuda et al., 2003b).
In addition, cilnidipine inhibited endogenous P2X7R expression in microglia and suppressed IL-1β release from microglia while relieving neuropathic pain (Yamashita et al., 2021). Thus, cilnidipine may alleviate DNP by inhibiting microglial reactivity while improving diabetic symptoms. Cilnidipine may provide a new research direction for DNP ...
17 sie 2022 · This review summarizes these emerging tools in studying the role of microglia in chronic pain and highlights their potential applications in microglia-related neurological disorders. Chronic pain relief remains an unmet medical need.
25 maj 2023 · Do CD11c + microglia have a pain-relieving action in this model, and in clinically relevant models of neuropathic pain such as chemotherapeutic and diabetic neuropathy? What are the molecular and cellular mechanisms responsible for the appearance of CD11c + microglia in the SDH after PNI?
