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28 kwi 2022 · In several recent meta-analyses of numerous studies enrolling people with type 2 diabetes, metformin treatment was associated with reduced risks of neurodegenerative diseases (e.g., Alzheimer’s disease, Parkinson’s disease, and others) and cognitive dysfunction compared to those not taking metformin, and risk reduction was more prominent in ...
15 gru 2021 · Metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with Alzheimer’s disease (AD), but the evidence of metformin on AD development was still ...
3 sie 2022 · To better understand the impact of metformin on the risk of dementia, we conducted a systematic review to determine if time-related biases have been addressed in previous observational studies that examined the association between metformin use and dementia risk among patients with diabetes.
25 paź 2023 · In this cohort study of metformin users, terminating metformin treatment was associated with increased dementia incidence, corroborating prior observational research that initiating metformin was associated with reduced risk of dementia.
27 sty 2022 · Most studies set the outcome as the onset of all-cause cognitive dysfunctions such as dementia and the participants as T2DM patients. A meta-analysis conducted in 2018 have shown that treatment with metformin could effectively lower the risk of subsequent dementia by 34% in elderly people with T2DM (Campbell et al., 2018).
1 lut 2019 · The findings suggested that metformin use in type 2 diabetes patients was associated with a significantly lower risk of dementia, especially when it had been used for more than 2 years (Table 2). The risk reduction showed a dose-response pattern and was consistent in sensitivity analyses (Table 3).
10 maj 2024 · This mini-narrative review explores the relationship between diabetes and dementia, focusing on the potential mitigating role of metformin in reducing cognitive decline among individuals with type 2 diabetes.
