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Results. The reference value of M2BPGi was 0.5–1.0 cut off index (COI) in the average risk group. Serum M2BPGi showed a positive correlation with metabolic parameters as well as age.
1 sty 2021 · Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serum marker for liver fibrosis. In this review, we discuss the role of M2BPGi in diagnosing liver fibrosis in chronic hepatitis B and C, chronic hepatitis C after sustained virologic response (SVR), and nonalcoholic fatty liver disease (NAFLD).
1 lis 2019 · Key Points. M2BPGi is increased in patients with liver graft-versus-host disease, especially in those at high risk for late NRM after allogeneic HSCT. WFA + -M2BP–positive macrophages are found in liver graft-versus-host disease, supporting these cells as a responder of this glycoprotein.
Mac-2 binding protein glycosylation isomer (M2BPGi) is a serum biomarker for liver fibrosis caused by chronic viral hepatitis and nonalcoholic fatty liver disease. [9,10] Although M2BPGi levels are correlated with liver fibrosis, serum M2BPGi values are increased in patients with acute liver injury suggesting M2BPGi may reflect liver ...
11 wrz 2020 · This test measures the anti-GPL core IgA antibodies in serum by the sandwich EIA method using microplates coated with a solid-phased antigen. An antibody titre of 0.7 U/mL or above is considered to be positive according to the recommendation of the manufacturer.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 10 6 cells in 100 µL volume or 100 µL of whole blood.
Hepatic stellate cells (HSCs) secrete M2BPGi, which may serve as a messenger between HSCs and Kupffer cells via Mac-2 (galectin 3) that is expressed in Kupffer cells during fibrosis progression. Here we show that M2BPGi is a surrogate marker for assessing HSC activation.
