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30 mar 2023 · In the present article, we describe evidence- and consensus-based guidelines for the definition and classification, diagnosis, and follow-up of patients with chronic neutropenias including special entities such as pregnancy and the neonatal period.
- Approach to the patient with neutropenia in childhood
The lower limit of neutropenia in newborns is 6 000/mm 3. As...
- Approach to the patient with neutropenia in childhood
1 wrz 2015 · The lower limit of neutropenia in newborns is 6 000/mm 3. As the baby grows up, this limit reduces to 1 000/mm 3 by the second week and this level is accepted to be normal up to the age of one year. After the age of one year the lower limit is 1 500/mm 3 .
10 gru 2021 · This article provides a diagnostic algorithm for evaluation of the pediatric and adult neutropenic patient followed by evidence-based approaches, where available, or expert consensus recommendations on the management of medical complications.
If the child is well, and there is a clear focus then samples may be limited to this area. In a neonate or infant, or in a child with chronic neutropenia, infection with hepatitis A, B and C, HIV, Epstein- Barr Virus and cytomegaloviris should be excluded. reticulocyte count, iron, folate and basic biochemistry.
It is important to distinguish between transient or benign causes and severe congenital neutropenia or neutropenia associated with serious haematological or systemic disease. Appropriate advice and treatment must be given while further assessment and investigation take place.
Febrile neutropenia can be life-threatening and requires prompt treatment with intravenous antibiotics, given according to local protocols and in line with the recent National Institute for Health and Care Excellence guidelines.
Low neutrophils are associated with elevated monocyte counts. Patients are particularly prone to Clostridium and gram-negative infections. Cyclical neutropenia is sometimes caused by mutations in the gene for the enzyme neutrophil elastase ELANE which impairs the survival of myeloid precursors.
