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5 lip 2022 · More recently, a growing body of literature has revealed new insights into ammonia metabolism in cancer cells to support growth and survival. Ammonia generated from amino acid catabolism upon glucose deprivation can stimulate autophagy and promote cancer cell survival (Eng et al., 2010).
6 lut 2019 · Therefore, in this study we aimed to screen a panel of cancer and non-cancerous cell lines for their ability to utilise ammonia as an alternative nitrogen source to support proliferation.
12 paź 2017 · Although lactate is well studied in cancer, little is known about the mechanisms by which cancer cells manage increased amounts of ammonia (NH 3) generated by glutamine and asparagine catabolism, de novo cysteine synthesis through the transsulfuration pathway, and salvage nucleotide metabolism .
5 lip 2022 · More recently, a growing body of literature has revealed new insights into ammonia metabolism in cancer cells to support growth and survival. Ammonia generated from amino acid catabolism upon glucose deprivation can stimulate autophagy and promote cancer cell survival (Eng et al., 2010).
24 sty 2020 · Some amino acids are produced by non-transaminase reactions. The best-known non-transaminase NEAA-synthesizing enzyme would be glutaminase (GLS). This amidohydrolase generates glutamate and ammonia from glutamine. GLS activity has been shown to be critical for most cancer cell growth, at least in monolayer culture 138,139. Because glutamate ...
9 wrz 2021 · Researchers have shown that an H + channel-like membrane transporter (SLC4A11), which is sensitive to ammonia, is expressed in both cancer cells and fibroblasts. SLC4A11 is located in the inner mitochondrial membrane of fibroblasts and is sensitive to ammonia.
21 cze 2017 · Nitrogen oxides have a long association with human diseases including cancer. The goal of this review is to give a brief overview of the biological sources, relevant biological reactions, and the associations with cancer of several biologically relevant nitrogen oxides categorized based on the oxidation state of the nitrogen.
