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5 lip 2022 · More recently, a growing body of literature has revealed new insights into ammonia metabolism in cancer cells to support growth and survival. Ammonia generated from amino acid catabolism upon glucose deprivation can stimulate autophagy and promote cancer cell survival (Eng et al., 2010).
11 wrz 2024 · Ammonia is thought to be a cytotoxin and its increase in the blood impairs cell function. However, whether and how this toxin triggers cell death under pathophysiological conditions remains...
26 lis 2020 · Here, we outline methodological approaches for measuring ICD markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer...
1 sty 2013 · The term hyperammonemia describes a clinical situation marked by increased plasma ammonia concentration. It is generally due to decreased ammonia detoxification as urea. Patients can be of any age. Since ammonia is neurotoxic, life and mental status can be threatened...
6 lut 2019 · We find that eleven cancer and non-cancerous cell lines have opposite abilities to tolerate and utilise ammonia to support proliferation in a glutamine-depleted environment.
9 wrz 2021 · Transport and metabolism of GLN and ammonia in cancer cells and CAFs. As mentioned earlier, cells depend on exogenous GLN as an N donor. Ammonia, which is metabolized using GLN, also plays an important role in regulating the metabolism of tumor cells and CAFs in the TME.
29 kwi 2022 · OVs in combination with CAR T-cells are promising candidates for overcoming the current drawbacks of CAR T-cell application in tumors through triggering immunogenic cell death (ICD) in cancer cells. ICD is a type of cellular death in which danger-associated molecular patterns (DAMPs) and tumor-specific antigens are released, leading to the ...
