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Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.
- Langerhans Cells—Revising Their Role in Skin Pathologies
(1) Langerhans cells (LCs) within the epidermis take up...
- The role of Langerhans cells in epidermal homeostasis and pathogenesis ...
Langerhans cells (LCs), as dendritic cells (DC) that play an...
- Langerhans Cells—Revising Their Role in Skin Pathologies
(1) Langerhans cells (LCs) within the epidermis take up antigen; (2) LCs internalize and process the antigen, and present the produced peptides on their surface via MHC molecules; (3) LCs migrate to the skin draining lymph nodes where they prime CD45RA + naïve T cells; (4) Activated T cells migrate to the skin, where they produce cytokines and ...
Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly distributed in the epidermis. This review focuses on the role of these epidermal LCs in regulating skin threats (such as microorganisms, ultraviolet radiation and allergens), especially psoriasis.
Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice...
15 kwi 2019 · One component of the skin defense system is the epidermis-resident Langerhans cell (LC). Here, we review the various roles and functions of LCs in a range of pathologies of the skin.
Langerhans cells derive from primitive erythro-myeloid progenitors that arise in the yolk sac outside the embryo in the first trimester of pregnancy, and under normal circumstances persist throughout life, being replenished by local proliferation as necessary.
Langerhans cells (immune cells). Special stains are often required to tell the difference between melanocytes and Langerhans cells. The Merkel cell is a fourth, less visible, epidermal cell.
