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The researchers discovered a strong genetic correlation between problematic alcohol use and 138 other conditions, including substance abuse disorders, depression, and schizophrenia. “AUD has many variants across the genome that are involved in the predisposition of this trait, but these variants are not only predisposing to AUD, they are ...
22 mar 2023 · Breakthrough findings could lead to more effective prevention and treatment strategies for multiple substance use disorders. By combing through genomic data of over 1 million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. This dataset – one of the largest of its ...
Briefly, findings from twin and family studies suggest common genetic factors shared amongst substance use (r g = 0.14–0.31 for alcohol, tobacco, and cannabis), with stronger estimates of shared genetic overlap amongst measures of problem use (r g = 0.56–0.62; Young, Rhee, Stallings, Corley, & Hewitt, 2006).
Although addiction is multifactorial, heritability estimates have indicated that around 40%–60% of the population variability in becoming addicted to nicotine, alcohol, or illicit drugs is attributable to genetic factors [3, 5]. Some genetic factors may influence an overarching susceptibility to developing addiction; thus, their effects are ...
28 sty 2019 · Accumulating evidence suggests that environmental factors, such as stress, induce epigenetic changes that can trigger the development of psychiatric disorders and drug addiction. Epigenetic changes refer to regulations of gene expression that do not involve alterations in the sequence of the genetic material (DNA) itself.
Alcohol use disorder (AUD) is a complex genetic disorder with very high heritability. This polygenic disorder not only results in increased morbidity and mortality, it is also a substantial social and economic burden on families and the nation.
1 lip 2005 · Genetic loci that have defined roles in addictions include substance-specific genes, such as the alcohol metabolic genes, and loci, such as the serotonin transporter and COMT, that alter...
