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22 mar 2023 · Dr. Hatoum and the research team discovered various molecular patterns underlying addiction, including 19 independent SNPs significantly associated with general addiction risk and 47 SNPs for specific substance disorders among the European ancestry sample.
Briefly, findings from twin and family studies suggest common genetic factors shared amongst substance use (r g = 0.14–0.31 for alcohol, tobacco, and cannabis), with stronger estimates of shared genetic overlap amongst measures of problem use (r g = 0.56–0.62; Young, Rhee, Stallings, Corley, & Hewitt, 2006).
As it turns out, there is no “alcoholic” gene in the human genome, nor is there an absolute “AUD-causing” environment or situation. Alcoholism has a substantial impact on both mental and physical health and can present different features among affected individuals.
4 maj 2022 · Collectively, genetic studies are providing persuasive evidence that there is underlying genetic liability that predisposes to both SUDs and chronic pain, depression, and COVID-19. For cardiometabolic disease, there is greater support for a potential causal influence of problematic substance use.
1 lip 2005 · Genetic loci that have defined roles in addictions include substance-specific genes, such as the alcohol metabolic genes, and loci, such as the serotonin transporter and COMT, that alter...
This review outlines GWAS reports to date for nicotine, alcohol, or other drug addictions and focuses on common variants (mostly, single nucleotide polymorphisms [SNPs]) with robust evidence for association (i.e., identified at the standard genome-wide significance threshold [P<5×10 −8] and replicated in an independent dataset).
Most candidate genes selected for AUD genetic association studies can broadly be divided into two categories: 1) genes involved in central nervous system’s (CNS) response to alcohol or other addictive substances (CHRNA5, GABRG1, GABRA2, OPRM1 etc.)[27, 31–35] and 2) genes involved in alcohol metabolism (ADH4, ADH1B, ALDH2)[36–41].
