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Recent years have brought substantial progress in advancing our understanding of the genetic architecture of SUDs and other substance use behaviors (e.g. consumption quantity), and relating these findings to etiologically-relevant processes for the development of SUDs.
22 mar 2023 · Dr. Hatoum and the research team discovered various molecular patterns underlying addiction, including 19 independent SNPs significantly associated with general addiction risk and 47 SNPs for specific substance disorders among the European ancestry sample.
3 gru 2012 · Spice abusers can be grouped in three main categories based upon previous drug use: 1) marijuana smokers, 2) occasional drug users seeking to avoid legal complications, and 3) drug-naïve, curious experimenters.
This review outlines GWAS reports to date for nicotine, alcohol, or other drug addictions and focuses on common variants (mostly, single nucleotide polymorphisms [SNPs]) with robust evidence for association (i.e., identified at the standard genome-wide significance threshold [P<5×10 −8] and replicated in an independent dataset).
This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, which is a complex multifactorial disorder. There is a large body of evidence showing that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling v ….
23 wrz 2016 · Spice is not a single drug, but a range of laboratory-made chemicals that mimic the effects of tetrahydrocannabinol (THC), the main psychoactive component of cannabis.
28 sty 2019 · Accumulating evidence suggests that environmental factors, such as stress, induce epigenetic changes that can trigger the development of psychiatric disorders and drug addiction. Epigenetic changes refer to regulations of gene expression that do not involve alterations in the sequence of the genetic material (DNA) itself.
