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6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
- PMC Free Article
Supplementation with oral iron provides 60–80 mg iron/day,...
- Ferfer
Introduction. According to the global anemia prevalence...
- Comparison Study of Iron Bioaccessibility From Dietary Supplements and Microencapsulated Preparations
In the form of lactate, one tablet of dietary supplements...
- A Review
Iron absorption generally starts from the first part of the...
- Impact of Ascorbic Acid on The In Vitro Iron Bioavailability of a Casein-Based Iron Fortificant
Interestingly, a similar enhancement (i.e., by 1.18-fold p <...
- Biochemical and Nutritional Characteristics of Buffalo Meat and Potential Implications on Human Health for a Personalized Nutrition
The human consumption of food animal products is the main...
- PubMed
Based on the Institute of Medicine's review of the...
- PMC Free Article
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
25 paź 2017 · Cellular iron intake and storage are regulated by the iron-responsive element and IRP system such that low iron concentrations favor the synthesis of more TFR1 and suppress ferritin expression, whereas high cellular iron leads to an increase in ferritin concentrations and a decrease in TFR1.
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
27 lis 2002 · In multicellular organisms, iron must be distributed from the site of absorption to cells that require iron. Genetic and molecular approaches have defined the mechanisms of iron uptake into absorptive cells and the subsequent transport of iron into plasma.
24 lis 2011 · The formation of red blood cells requires about 30 mg of iron daily and this is balanced by an equal flux of iron from the breakdown of senescent red blood cells by the reticuloendothelial (RE) cells in the spleen, liver (Kupffer cells), and bone marrow.
Iron in cells can be used for cellular processes or stored in the cytosolic protein ferritin. Levels of iron transporters, carriers and storage proteins are regulated transcriptionally and...
