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4 sie 2017 · Enterocytes in the proximal small intestine absorb dietary iron; erythrocyte precursors in the bone marrow incorporate iron into heme in red blood cell (RBC) hemoglobin; macrophages in the liver, spleen, and bone marrow recycle iron from senescent RBCs; and hepatocytes store iron (Fig. 1).
8 sie 2014 · Iron absorption is precisely regulated by a range of systemic and cellular mediators (Fig. 2). Liver-derived, circulating HEPC regulates duodenal iron absorption and also modulates iron release from stores in hepatocytes and RE macrophages (which recycle iron from senescent erythrocytes).
6 sty 2011 · The intracellular step of iron absorption refers to the intracellular distribution of the newly transported iron to the basolateral surface, to the mitochondria (e.g., biosynthesis of heme and iron-sulfur cluster), or to iron binding proteins (e.g., non-heme iron binding proteins and ferritin).
27 lis 2002 · In multicellular organisms, iron must be distributed from the site of absorption to cells that require iron. Genetic and molecular approaches have defined the mechanisms of iron uptake into absorptive cells and the subsequent transport of iron into plasma.
6 cze 2022 · Iron homeostasis is mainly controlled by intestinal absorption because iron does not have active excretory mechanisms for humans. Thus, efficient intestinal iron bioavailability is essential to reduce the risk of iron deficiency anemia. There are two forms of iron, heme and nonheme, found in foods.
1 mar 1998 · This review summarizes current knowledge of and hypotheses on each of the three steps of iron absorption: uptake from the intestinal lumen into mucosal cells, transit through the cell, and release from the cells into the body.
22 mar 2024 · Cellular iron homeostasis is primarily regulated post-transcriptionally upon binding of iron regulatory proteins (IRP1 and IRP2) to iron-responsive elements (IREs) in the untranslated regions of the mRNAs for key proteins of iron metabolism (Figure 1A).
