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A prime example of this is the role of interferon-τ (IFNτ), a unique type I IFN, that is essential for pregnancy recognition in ungulates (Roberts, 2007). IFNτ is expressed by the early trophoectoderm and acts as a hormone of pregnancy recognition to rescue the corpus luteum.
18 wrz 2018 · A prime example of this is the role of interferon-τ (IFN-τ), a unique type I IFN that is essential for pregnancy recognition in ungulates (Roberts, 2007). IFN-τ is expressed by the early trophoectoderm and acts as a hormone of pregnancy recognition to rescue the corpus luteum.
13 sty 2020 · In this review, we discuss the antiviral and pathogenic effects of type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), and type III IFN (IFN-λ) during pregnancy, with an emphasis on mouse and non-human primate models of congenital Zika virus infection. In the context of these animal model systems, we examine the role of IFN signaling during ...
19 lis 2019 · The interferon epigenomic signature affects ISGs and other gene sets, including canonical targets of the transcription factor NF-κB that encode inflammatory molecules, and is involved in the...
19 cze 2018 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated...
Interferon gamma (IFNG) is a proinflammatory cytokine secreted in the uterus during early pregnancy. It is abundantly produced by uterine natural killer cells in maternal endometrium but also by trophoblasts in some species.
Interferons activate the Jak-STAT signaling pathway and induce overlapping patterns of expression, called 'interferon signatures', of canonical interferon-stimulated genes (ISGs) encoding molecules important for antiviral responses, antigen presentation, autoimmunity and inflammation.
