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1 paź 2019 · A pooled analysis of six clinical trials showed that, in patients with optimized basal insulin therapy, elevated A1C (≥7.0%) with fasting glucose levels <130 mg/dL indicates a need to intensify therapy for PPG excursions to improve glycemic control rather than continue basal insulin titration (49).
2. Titrate slowly over 1-2 weeks (500 mg increments and always with food) 3. Use of extended release highly recommended 4. Continue full dosing if GFR > 45 cc/min 5. Reduce to 500 mg BID if GFR 30-45 cc/min 6. STOP Metformin if GFR less than 30 Metformin Monotherapy
24 cze 2021 · Basal insulin is usually initiated at a conservative dose of 10 units/day or 0.1–0.2 units/kg/day, then titrated thereafter over several weeks or months, based on patients’ self-measured fasting plasma glucose, to achieve an individualized target (usually 80–130 mg/dL).
28 sie 2024 · This topic will review the use of insulin therapy in nonpregnant patients with type 2 diabetes. The approach to initial pharmacotherapy and the management of persistent hyperglycemia are discussed separately, as are other therapeutic issues in diabetes management.
May consider self titrating basal insulin by increasing dose 1 unit every day until average fasting glucose is < 130, if that is easier for the patient to understand. Self titration of small doses may be easiest for patients using insulin pens.
4-T Insulin Titration Algorithm. Prior to each visit and telephone contact patients are asked to perform three self-measured capillary glucose profiles, before breakfast and the evening...
Algorithm for the Management of Type 2 Diabetes. STEP 1 – Initial Drug Treatment – Monotherapy: Target HbA1c 48 mmol/mol. Lifestyle advice + Referral to Good2Go Metformin (consider 3 months lifestyle change first) Consider trial of modified-release metformin in patients who experience gastrointestinal side effects with standard release metformin.
