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A mature hair follicle is composed of a central keratinized fiber, called the hair shaft, that is directly surrounded by layers of terminally differentiated keratinocytes called the inner root sheath. The entire structure is lined externally by a single layer of undifferentiated basal cells that comprise the outer root sheath.
Once in anagen, stem cells exit the bulge and migrate down the basal layer of the follicle where they proliferate and contribute to the outer epithelial layer known as the outer root sheath. The outer root sheath contains hair keratinocytes that express the cytoskeletal protein Krt14.
7 sty 2011 · As matrix cells move upward, they terminally differentiate into one of the seven distinct lineages that are spatially organized into concentric rings in an onion-like fashion: the medulla, cortex and cuticle of the hair shaft; the cuticle, Henle and Huxley layers of the inner root sheath (IRS), and the companion layer (Cp), which is sandwiched ...
The inner root sheath or internal root sheath of the hair follicle is located between the outer root sheath and the hair shaft. [1] It is made of three layers: Henle's layer, Huxley's layer, and the cuticle. [2] The inner root sheaf serves to protect growing hair. [3]
The internal root sheath is a layer composed of lightly keratinized cells which envelops the lower portion of the hair shaft, it does not extend past the isthmus (the middle segment) of the hair follicle.
10 lut 2009 · During catagen, the lower two-thirds of the hair follicle rapidly regress, mainly by apoptosis of matrix, inner root sheath and outer root sheath keratinocytes, while bulge hair follicle stem cells escape apoptosis.
The inner root sheath is composed of four layers: Companion layer (CL), Henle’s layer, Huxley’s layer, and the inner root sheath cuticle. The companion layer cells are tightly bound to Henle’s layer, but not to the outer root sheath, thus allowing the companion layer to function as a slippage plane between the stationary outer root sheath ...
