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Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells cannot regenerate, this damage is permanent. [4]
3 sty 2020 · Sensory hair cells of the inner ear rely on the hair bundle, a cluster of actin-filled stereocilia, to transduce auditory and vestibular stimuli into electrical impulses. Because they are long and thin projections, stereocilia are most prone to damage at the point where they insert into the hair cell’s soma.
6 cze 2024 · Mammalian inner ear hair cell loss leads to permanent hearing and balance dysfunction. In contrast to the cochlea, vestibular hair cells of the murine utricle have some regenerative capacity.
19 kwi 2023 · Scientists are examining different gene therapy and surgical methods, including an approach previously honed at Mass Eye and Ear, in which a different viral vector called an adeno-associated virus (AAV) was able to precisely and safely deliver gene therapy to the inner ear through a novel surgery.
Scientists identify new pathway that may enable the inner ear to be reprogrammed to grow lost hair cells, which could help develop treatments to restore hearing.
1 lip 2004 · The mammalian inner ear is a sensory organ that has specialized hair cells that detect sound, as well as orientation and movement of the head. The 'hair' bundle on the apical surface of these...
25 maj 2018 · The inner ear has two primary components: the cochlea and the vestibular apparatus (semicircular canals, utricle, and saccule). The cochlea is responsible for hearing and the vestibular apparatus is responsible for balance and position.
