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4 kwi 2022 · What are the biological basis and valid drug targets of NASH? What are the key regulatory issues? How to overcome the obstacles ahead on the road to the first NASH drug?
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Cover Credit: Lonicerin (LCR), a bioactive compound found in...
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4 mar 2021 · Globally, the incidence of liver cirrhosis caused by NASH increased from 178,430 cases in 1990 to 367,780 cases in 2017, an increase of approximately 105.56%.
7 gru 2023 · Following the FDA’s acceptance of Madrigal Pharmaceuticals’ new drug application (NDA) and priority review for its THR-β agonist (resmetirom) in non-alcoholic steatohepatitis (NASH) in September 2023, the company has taken steps to fortify its leadership and financial position to gear up for the imminent launch of resmetirom.
Although multiple potential targets for drug development exist, there have been no approved therapies for NAFLD/NASH. Lipotoxicity, owing to increased delivery of fatty acids to the liver, and hepatic de novo lipogenesis are key drivers of disease pathogenesis.
6 dni temu · Prepare for an unparalleled musical experience as “Our House: The Music of CSNY” assembles to perform the Crosby, Stills, Nash & Young repertoire with an extraordinary ensemble of Family & Friends.
31 paź 2024 · Stephen Stills talks about discovering tapes of one of CSNY's first shows, his renewed relationship with Neil Young, and the memory of David Crosby.
14 kwi 2020 · TARGET-NASH is now the largest active observational and longitudinal NASH-specific study in the world. “TARGET-NASH has reached 5,000 enrolled patients in only its fourth year of data collection,” said TARGET PharmaSolutions CEO, Neal Bibeau.