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Glucose metabolism provides the fuel for physiological brain function through the generation of ATP, the foundation for neuronal and non-neuronal cellular maintenance, as well as the generation of neurotransmitters.
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Generation of energy in brain and three models for the fate...
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Because the brain is so rich in nerve cells, or neurons, it is the most energy-demanding organ, using one-half of all the sugar energy in the body. Brain functions such as thinking, memory, and learning are closely linked to glucose levels and how efficiently the brain uses this fuel source.
Glucose is the essential metabolic fuel for the brain. Acute and severe reduction of brain glucose leads quickly to impairment of cognitive and reflex function, autonomic failure, seizures, loss of consciousness, and permanent and irreversible brain damage and, if not rapidly corrected, can be lethal.
4 lip 2018 · In this review, we present an overview of the brain regions, peripheral nerves and molecular mechanisms by which the CNS regulates glucose metabolism and the potential benefits of modulating them for diabetes management.
21 cze 2021 · Abstract. Growing evidence implicates the brain in the regulation of both immediate fuel availability (for example, circulating glucose) and long-term energy stores (that is, adipose...
21 lip 2017 · The notion that the central nervous system (CNS) is crucial for the physiological control of glucose homeostasis is increasingly recognized. Hypothalamic neurons that regulate energy balance, glucose production, and utilization constantly sense fuel availability by...
19 gru 2018 · The major role for glucose, particularly in adult brain, is generation of ATP, but it is also essential for synthesis of compounds required for signaling, management of oxidative stress, and brain structure and remodeling. Glucose metabolism is tightly regulated and fluxes through different pathways change with physiological status.
