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5 cze 2024 · Small studies have shown a pathological complete response to neoadjuvant anti–PD-1 monotherapy in high percentages of patients with dMMR colorectal cancer. 12,30 In these studies, patients...
28 sty 2021 · In this review, we summarize the most recent advances in immunotherapy based on the findings of pivotal clinical trials for patients with mCRC, highlighting potent therapeutic approaches and predictive biomarkers.
19 sty 2024 · This review summarizes the most crucial new immunotherapy methods under investigation for colorectal cancer treatment, including Immune checkpoint inhibitors, CAR-T cell therapy, BiTEs, Tumor-infiltrating lymphocytes, and Oncolytic virus therapy.
It is important to note that clinical trials for patients with MMR-D/MSI-H colon cancer with or without organ preservation should consider DFS and OS as their primary end point to elucidate the clinical benefits of ICI therapy over historical oxaliplatin-based adjuvant therapy.
1 cze 2020 · This literature review evaluates the current role of immunotherapy in advanced colorectal cancer, potential challenges clinicians face with immunotherapy-based regimens, and the possible future approach of combined modality immunotherapy.
18 mar 2019 · Ganesh et al. describe the rationale for using immunotherapy in select patients with colorectal cancer, discuss clinical findings supporting its use and highlight current strategies and...
10 sie 2023 · Abstract. Colorectal cancer (CRC) is a common and deadly disease. Unfortunately, immune checkpoint inhibitors (ICIs) fail to elicit effective anti-tumour responses in the vast majority of CRC...
